John Franklin Enders (February 10, 1897 – September 8, 1985) was an American biomedical scientist and Nobel laureate. He had been called "The Father of Modern Vaccines". He was born in West Hartford, Connecticut. His father, John Ostrom Ender, was CEO of the Hartford National Bank and left him a fortune of $19 million upon his death. Heattended the Noah Webster School in Hartford, and St. Paul's School in Concord, New Hampshire. After attending Yale University a short time, he joined the United States Army Air Corps in 1918 as a flight instructor and a lieutenant.
After returning from World War I, he graduated from Yale, where he was a member of Scroll and Key as well as Delta Kappa Epsilon. He went into real estate in 1922, and tried several careers before choosing the biomedical field with a focus on infectious diseases, gaining a Ph.D. at Harvard in 1930. He later joined the faculty at Children's Hospital Boston. Enders died in 1985 in Waterford, Connecticut, aged 88,holding honorary doctoral degrees from 13 universities.
In 1949, Enders, Thomas Huckle Weller, and Frederick Chapman Robbins reported successful in vitro culture of an animal virus—poliovirus. The three received the 1954 Nobel Prize in Physiology or Medicine "for their discovery of the ability of polioviruses to grow in cultures of various types of tissue". Meanwhile, Jonas Salk applied the Enders-Weller-Robbins technique to produce large quantities of poliovirus, and then develop a polio vaccine in 1952. Upon the 1954 polio vaccine field trial, whose success Salk announced on the radio, Salk became a public hero eye but failed to credit the many other researchers that his effort rode upon, and was somewhat shunned by America's scientific establishment.
In 1954, Enders and Peebles isolated measlesvirus from an 11-year-old boy, David Edmonston. Disappointed by polio vaccine's development and involvement in some cases of polio and death—what Enders attributed to Salk's technique—Enders began development of measles vaccine. In October 1960, an Enders team began trials on 1,500 mentally retarded children in New York City and on 4,000 children in Nigeria. On 17 September 1961, New York Times announced the measles vaccine effective. Refusing credit for only himself, Enders stressed the collaborative nature of the effort. In 1963, Pfizer introduced a deactivated measles vaccine, and Merck & Co introduced an attenuated measles vaccine.
Wilhelm Conrad Röntgen (27 March 1845 – 10 February 1923) was a German physicist, who, on 8 November 1895,produced and detected electromagnetic radiation in a wavelength range today that was known as X-rays or Röntgen rays, an achievement that earned him the first Nobel Prize in Physics in 1901. In honour of his accomplishments, in 2004 the International Union of Pure and Applied Chemistry(IUPAC) named element 111, roentgenium, a radioactive element with multiple unstable isotopes, after him.
In 1865, he tried to attend the University of Utrecht without having the necessary credentials required for a regular student. Upon hearing that he could enter the Federal Polytechnic Institute in Zurich (today known as the ETH Zurich), he passed its examinations, and began studies there as a student of mechanical engineering. In 1869, he graduated with a Ph.D. from the University of Zurich; once there, he became a favorite student of Professor August Kundt, whom he followed to the University of Strassburg (then recently annexed by Germany) in 1873.
During 1895 Röntgen was investigating the external effects from the various types of vacuum tube equipment — apparatuses from Heinrich Hertz,Johann Hittorf, William Crookes, Nikola Tesla and Philipp von Lenard — when an electrical discharge is passed through them. In early November, he was repeating an experiment with one of Lenard's tubes in which a thin aluminium window had been added to permit the cathode rays to exit the tube but a cardboard covering was added to protect the aluminium from damage by the strong electrostatic field that is necessary to produce the cathode rays.
He knew the cardboard covering prevented light from escaping, yet Röntgen observed that the invisible cathode rays caused afluorescent effect on a small cardboard screen painted with barium platinocyanide when it was placed close to the aluminium window. It occurred to Röntgen that the Hittorf-Crookes tube, which had a much thicker glass wall than the Lenard tube, might also cause this fluorescent effect.
In the late afternoon of 8 November 1895, Röntgen determined to test his idea. He carefully constructed a black cardboard covering similar to the one he had used on the Lenard tube. He covered the Hittorf-Crookes tube with the cardboard and attached electrodes to a Ruhmkorff coil to generate an electrostatic charge. Before setting up the barium platinocyanide screen to test his idea, Röntgen darkened the room to test the opacity of his cardboard cover. As he passed the Ruhmkorff coil charge through the tube, he determined that the cover was light-tight and turned to prepare the next step of the experiment.
It was at this point that Röntgen noticed a faint shimmering from a bench a few feet away from the tube. To be sure, he tried several more discharges and saw the same shimmering each time. Striking a match, he discovered the shimmering had come from the location of the barium platinocyanide screen he had been intending to use next.
Röntgen speculated that a new kind of ray might be responsible. 8 November was a Friday, so he took advantage of the weekend to repeat his experiments and make his first notes. In the following weeks he ate and slept in his laboratory as he investigated many properties of the new rays he temporarily termed "X-rays", using the mathematical designation for something unknown. The new rays came to bear his name in many languages as "Röntgen Rays" (and the associated X-ray radiograms as "Röntgenograms"). Nearly two weeks after his discovery, he took the very first picture using X-rays of his wife Anna Bertha's hand. When she saw her skeleton she exclaimed "I have seen my death!"
At one point while he was investigating the ability of various materials to stop the rays, Röntgen brought a small piece of lead into position while a discharge was occurring. Röntgen thus saw the first radiographic image, his own flickering ghostly skeleton on the barium platinocyanide screen. He later reported that it was at this point that he determined to continue his experiments in secrecy, because he feared for his professional reputation if his observations were in error.
Röntgen's original paper, "On A New Kind Of Rays" (Über eine neue Art von Strahlen), was published on 28 December 1895. On 5 January 1896, an Austrian newspaper reported Röntgen's discovery of a new type of radiation. Röntgen was awarded an honorary Doctor of Medicine degree from the University of Würzburg after his discovery. He published a total of three papers on X-rays between 1895 and 1897. Today, Röntgen is considered the father of diagnostic radiology, the medical speciality which uses imaging to diagnose disease.
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