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Gerolamo (or Girolamo, or Geronimo) Cardano (24 September 1501 – 21 September 1576) was an Italian Renaissance mathematician, physician, astrologer, philosopher and gambler. He wrote more than 200 works on medicine, mathematics, physics, philosophy, religion, and music. His gambling led him to formulate elementary rules in probability, making him one of the founders of the field. He was born in Pavia, Lombardy, the child of Fazio Cardano, a mathematically gifted lawyer, who was a friend of Leonardo da Vinci. In his autobiography, Cardano claimed that his mother had attempted to abort him.

In 1520, he entered the University of Pavia and later in Padua studied medicine. His eccentric and confrontational style did not earn him many friends and he had a difficult time finding work after his studies ended. In 1525, Cardano repeatedly applied to the College of Physicians in Milan, but was not admitted owing to his combative reputation and illegitimate birth. Eventually, he managed to develop a considerable reputation as a physician and his services were highly valued at the courts. He was the first to describe typhoid fever. In 1553 he cured the Scottish Archbishop of St Andrews of a disease that had left him speechless and was thought incurable. The diplomat Thomas Randolph recorded the "merry tales" rumoured about his methods still current in Edinburgh nine years later. Cardano himself wrote that the Archbishop had been short of breath for ten years, and after the cure was effected by his assistant, he was paid 1,400 gold crowns.

Today, he is best known for his achievements in algebra. Cardano was the first mathematician to make systematic use of numbers less than zero. He published the solutions to the cubic and quartic equations in his 1545 book Ars Magna. Cardano was notoriously short of money and kept himself solvent by being an accomplished gambler and chess player. His book about games of chance, Liber de ludo aleae ("Book on Games of Chance"), written around 1564, but not published until 1663, contains the first systematic treatment of probability, as well as a section on effective cheating methods. He used the game of throwing dice to understand the basic concepts of probability. He demonstrated the efficacy of defining odds as the ratio of favourable to unfavourable outcomes (which implies that the probability of an event is given by the ratio of favourable outcomes to the total number of possible outcomes).

He was also aware of the multiplication rule for independent events but was not certain about what values should be multiplied. Cardano invented several mechanical devices including the combination lock, the gimbal consisting of three concentric rings allowing a supported compass or gyroscope to rotate freely, and the Cardan shaft with universal joints, which allows the transmission of rotary motion at various angles and is used in vehicles to this day. He studied hypocycloids, published in de proportionibus 1570. The generating circles of these hypocycloids were later named Cardano circles or cardanic circles and were used for the construction of the first high-speed printing presses.

He made several contributions to hydrodynamics and held that perpetual motion is impossible, except in celestial bodies. He published two encyclopedias of natural science which contain a wide variety of inventions, facts, and occult superstitions. He also introduced the Cardan grille, a cryptographic tool, in 1550.

Significantly, in the history of education of the deaf, he said that deaf people were capable of using their minds, argued for the importance of teaching them, and was one of the first to state that deaf people could learn to read and write without learning how to speak first. He was familiar with a report by Rudolph Agricola about a deaf mute who had learned to write.

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