Robert Heinrich Herman Koch (11 December 1843 – 27 May 1910) was a celebrated German physician and pioneering microbiologist. The founder of modern bacteriology, he is known for his role in identifying the specific causative agents of tuberculosis, cholera, and anthrax and for giving experimental support for the concept of infectious disease. He created and improved laboratory technologies and techniques in the field of microbiology, and made key discoveries in public health. His research led to the creation of Koch’s postulates, a series of four generalized principles linking specific microorganisms to specific diseases that remain today the "gold standard" in medical microbiology. As a result of his groundbreaking research on tuberculosis, Koch received the Nobel Prize in Physiology or Medicine in 1905.
Robert Koch was born in Clausthal, Hanover, Germany, on 11 December 1843, to Hermann Koch and Mathilde Julie Henriette Biewand. Koch excelled in academics from an early age. Before entering school in 1848, he had taught himself how to read and write. He graduated from high school in 1862, having excelled in science and maths. At the age of 19, Koch entered the University of Göttingen, studying natural science. However, after two semesters, Koch decided to change his area of study to medicine, as he aspired to be a physician. During his fifth semester of medical school, Jacob Henle, an anatomist who had published a theory of contagion in 1840, asked him to participate in his research project on uterine nerve structure.
In his sixth semester, Koch began to conduct research at the Physiological Institute, where he studied succinic acid secretion. This would eventually form the basis of his dissertation. In January 1866, Koch graduated from medical school, earning honors of the highest distinction. After his graduation in 1866, he worked as a surgeon in the Franco-Prussian War, and following his service, worked as a physician in Wollstein (now Wolsztyn, Poland).
From 1885 to 1890, he served as an administrator and professor at Berlin University. Koch suffered a heart attack on 9 April 1910, and never made a complete recovery. On 27 May, only three days after giving a lecture on his tuberculosis research at the Berlin Academy of Sciences, Robert Koch died in Baden-Baden at the age of 66. Following his death, the Institute named its establishment after him in his honor.
Robert Koch is widely known for his work with anthrax, discovering the causative agent of the fatal disease to be Bacillus anthracis. Koch discovered the formation in anthrax bacteria of spores that could remain dormant under specific conditions. However, under optimal conditions, the spores were activated and caused disease. To determine this causative agent, he dry-fixed bacterial cultures onto glass slides, used dyes to stain the cultures, and observed them through a microscope.
During his time as government advisor, he published a report in which he stated the importance of pure cultures in isolating disease-causing organisms and explained the necessary steps to obtain these cultures, methods which are summarized in Koch’s four postulates. Koch’s discovery of the causative agent of anthrax led to the formation of a generic set of postulates which can be used in the determination of the cause of any infectious disease.
These postulates, which not only outlined a method for linking cause and effect of an infectious disease but also established the significance of laboratory culture of infectious agents, are listed here: 1. The organism must always be present, in every case of the disease. 2. The organism must be isolated from a host containing the disease and grown in pure culture. 3. Samples of the organism taken from pure culture must cause the same disease when inoculated into a healthy, susceptible animal in the laboratory. 4. The organism must be isolated from the inoculated animal and must be identified as the same original organism first isolated from the originally diseased host.
Koch next turned his attention to cholera, and began to conduct research in Egypt in the hopes of isolating the causative agent of the disease. Subsequently traveled to India to continue with the study. In India, Koch was indeed able to determine the causative agent of cholera, isolating Vibrio cholera. The bacterium had originally been isolated in 1854 by Italian anatomist Filippo Pacini, but its exact nature and his results were not widely known.
At that time, it was widely believed that tuberculosis was an inherited disease. However, Koch was convinced that the disease was caused by a bacterium and was infectious, and tested his four postulates using guinea pigs. In 1882, he published his findings on tuberculosis, in which he reported the causative agent of the disease to be the slow-growing Mycobacterium tuberculosis. His work with this disease won Koch the Nobel Prize in Physiology and Medicine in 1905. Additionally, Koch's research on tuberculosis, along with his studies on tropical diseases, won him the Prussian Order Pour le Merite in 1906 and the Robert Koch medal, established to honor the greatest living physicians, in 1908.
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